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Randomized controlled trial using bosentan to enhance the impact of exercise training in subjects with type 2 diabetes mellitus

Schreuder, THA and Duncker, DJ and Hopman, MTE and Thijssen, DHJ (2014) Randomized controlled trial using bosentan to enhance the impact of exercise training in subjects with type 2 diabetes mellitus. Experimental Physiology, 99 (11). ISSN 1469-445X

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Abstract

In type 2 diabetes patients, endothelin (ET) receptor blockade may enhance blood flow responses to exercise training. The combination of exercise training and ET receptor blockade may represent a more potent stimulus than training alone to improve vascular function, physical fitness and glucose homeostasis. We assessed the effect of an 8 week exercise training programme combined with either ET blockade or placebo on vasculature, fitness and glucose homeostasis in people with type 2 diabetes. In a double-blind randomized controlled trial, brachial endothelium-dependent and -independent dilatation (using flow-mediated dilatation and glyceryl trinitrate, respectively), glucose homeostasis (using Homeostasis Model Assessment for Insulin Resistance (HOMA-IR)) and physical fitness (maximal cycling test) were assessed in 18 men with type 2 diabetes (60 ± 6 years old). Subjects underwent an 8 week exercise training programme, with half of the subjects receiving ET receptor blockade (bosentan) and the other half a placebo, followed by reassessment of the tests above. Exercise training improved physical fitness to a similar extent in both groups, but we did not detect changes in vascular function in either group. This study suggests that there is no adaptation in brachial and femoral artery endothelial function after 8 weeks of training in type 2 diabetes patients. Endothelin receptor blockade combined with exercise training does not additionally alter conduit artery endothelial function or physical fitness in type 2 diabetes.

Item Type: Article
Additional Information: This is the accepted version of the following article: Schreuder, T. H. A., Duncker, D. J., Hopman, M. T. E. and Thijssen, D. H. J. (2014), Randomized controlled trial using bosentan to enhance the impact of exercise training in subjects with type 2 diabetes mellitus. Exp Physiol, 99: 1538–1547, which has been published in final form at http://dx.doi.org/10.1113/expphysiol.2014.081182
Uncontrolled Keywords: 0606 Physiology, 1116 Medical Physiology, 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 22 Jan 2016 12:04
Last Modified: 22 Jan 2016 12:04
DOI or Identification number: 10.1113/expphysiol.2014.081182
URI: http://researchonline.ljmu.ac.uk/id/eprint/2757

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