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Isolation, identification and antiproliferative activity of triterpenes from the genus Monotheca A. DC.

Javed, S and Oise, IE and Nahar, L and Ismail, FMD and Mahmood, Z and Sarker, SD (2016) Isolation, identification and antiproliferative activity of triterpenes from the genus Monotheca A. DC. Records of Natural Products, 10 (6). pp. 782-787. ISSN 1307-6167

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Abstract

The Monotheca A. DC. is a monotypic genus of the family Sapotaceae, which is widely distributed in Afghanistan, Djbouti, Northern Somalia, Oman, Pakistan and Southern Ethiopia. North-west Pakistan is the main region where Monotheca buxifolia (Falc.) A. DC., the only species of this genus, locally known as “Gurgura”, grows abundantly. It is an evergreen, fruit-producing medicinal tree. Bioassay-guided fractionation of the aerial parts of M. buxifolia afforded lupeol (1), lupeol acetate (2), betulin (3), oleanolic acid (4) and β-amyrin (5) from the n-hexane and the chloroform fractions. This is the first report on the isolation, and identification of triterpenes (1-5) as the major compounds in the active fractions with antiproliferative property, and also on the antiproliferative activity of M. buxifolia extract and fractions against the human lung cancer cell line NCI-H460 in vitro.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: ACG Publications
Date Deposited: 29 Jan 2016 16:15
Last Modified: 07 Sep 2017 00:25
URI: http://researchonline.ljmu.ac.uk/id/eprint/2789

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