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Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes

Neafsey, DE and Waterhouse, RM and Abai, MR and Aganezov, SS and Alekseyev, MA and Allen, JE and Amon, J and Arca, B and Arensburger, P and Artemov, G and Assour, LA and Basseri, H and Berlin, A and Birren, BW and Blandin, SA and Brockman, AI and Burkot, TR and Burt, A and Chan, CS and Chauve, C and Chiu, JC and Christensen, M and Costantini, C and Davidson, VLM and Deligianni, E and Dottorini, T and Dritsou, V and Gabriel, SB and Guelbeogo, WM and Hall, AB and Han, MV and Hlaing, T and Hughes, DST and Jenkins, AM and Jiang, X and Jungreis, I and Kakani, EG and Kamali, M and Kemppainen, P and Kennedy, RC and Kirmitzoglou, IK and Koekemoer, LL and Laban, N and Langridge, N and Lawniczak, MKN and Lirakis, M and Lobo, NF and Lowy, E and MacCallum, RM and Mao, C and Maslen, G and Mbogo, C and McCarthy, J and Michel, K and Mitchell, SN and Moore, W and Murphy, KA and Naumenko, AN and Nolan, T and Novoa, EM and O'Loughlin, S and Oringanje, C and Oshaghi, MA and Pakpour, N and Papathanos, PA and Peery, AN and Povelones, M and Prakash, A and Price, DP and Rajaraman, A and Reimer, LJ and Rinker, DC and Rokas, A and Russell, TL and Sagnon, N and Sharakhova, MV and Shea, T and Simao, FA and Simard, F and Slotman, MA and Somboon, P and Stegniy, V and Struchiner, CJ and Thomas, GWC and Tojo, M and Topalis, P and Tubio, JMC and Unger, MF and Vontas, J and Walton, C and Wilding, CS and Willis, JH and Wu, Y-C and Yan, G and Zdobnov, EM and Zhou, X and Catteruccia, F and Christophides, GK and Collins, FH and Cornman, RS and Crisanti, A and Donnelly, MJ and Emrich, SJ and Fontaine, MC and Gelbart, W and Hahn, MW and Hansen, IA and Howell, PI and Kafatos, FC and Kellis, M and Lawson, D and Louis, C and Luckhart, S and Muskavitch, MAT and Ribeiro, JM and Riehle, MA and Sharakhov, IV and Tu, Z and Zwiebel, LJ and Besansky, NJ (2015) Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes. SCIENCE, 347 (6217). pp. 1258522-125822. ISSN 0036-8075

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Abstract

Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover, but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.

Item Type: Article
Uncontrolled Keywords: MD Multidisciplinary
Subjects: Q Science > QL Zoology
Divisions: Natural Sciences and Psychology
Publisher: American Association for the Advancement of Science
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Date Deposited: 18 Jan 2016 11:03
Last Modified: 18 Jan 2016 11:03
DOI or Identification number: 10.1126/science.1258522
URI: http://researchonline.ljmu.ac.uk/id/eprint/303

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