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On drug-base incompatibilities during extrudate manufacture and fused deposition 3D printing

Davies, MJ and Costley, M and Ren, J and Gibbons, P and Kondor, A and Naderi, M (2017) On drug-base incompatibilities during extrudate manufacture and fused deposition 3D printing. Journal of 3D Printing in Medicine, 1 (1). pp. 31-47. ISSN 2059-4755

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Abstract

Aim: 3D printing can be applied for point-of-care personalized treatment. This study aimed to determine the manufacturability and characteristics of 3D printed, drug loaded implants for alcohol misuse. Materials & methods: Disulfiram was the drug substance used and polylactic acid (PLA) the base material. Implantable devices were designed in silico. Drug and PLA were placed into the extruder to produce a 5% blend at 1.75-mm diameter. Material characterization included differential scanning calorimetry, thermogravimetric analysis plus inverse GC-surface energy analyzer. Results: Implantable constructs from the PLA feedstock were acquired. The extrusion processes had a detrimental effect on the active pharmaceutical ingredient-base blend. differential scanning calorimetry and thermogravimetric analysis analysis indicated drug–base interactions. Thermal history was found to influence inverse GC probe interaction. Conclusion: Drug-base incompatibilities must be considered during 3D printing.

Item Type: Article
Additional Information: This is an accepted article published in full at: Davies, M.J et al. On drug-base incompatibilities during extrudate manufacture and fused deposition 3D printing. Journal of 3D Printing in Medicine. 1(1), pp31-47 DOI: 10.2217/3dp-2016-0006
Subjects: R Medicine > RM Therapeutics. Pharmacology
T Technology > TJ Mechanical engineering and machinery
Divisions: Maritime and Mechanical Engineering
Pharmacy & Biomolecular Sciences
Publisher: Future Medicine
Date Deposited: 12 Jan 2017 11:58
Last Modified: 07 Sep 2017 12:42
DOI or Identification number: 10.2217/3dp-2016-0006
URI: http://researchonline.ljmu.ac.uk/id/eprint/5254

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