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Dyes, flies, and sunny skies: photodynamic therapy and neglected tropical diseases

Wainwright, M (2017) Dyes, flies, and sunny skies: photodynamic therapy and neglected tropical diseases. Coloration Technology, 133 (1). pp. 3-14. ISSN 1472-3581

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Abstract

Photodynamic therapy, in its various applications, represents the focused combination of electromagnetic radiation, a chemical (usually a dye) capable of its absorption and conversion, and oxygen to provide cytotoxicity (cell killing). The effect has been known for over a century, and there is considerable clinical use in terms of its application to various cancers. However, the antimicrobial properties of the technology, which are considerable, have received only a lukewarm reception by healthcare providers, and the possibilities for tropical disease therapy are mainly unexplored. This is particularly vexatious given both the inexpensive nature of the photosensitisers and light sources available and the lack of conventional forward progress in widespread diseases such as leishmaniasis, trypanosomiasis, and tuberculosis in the Developing World. The following review therefore covers the use, or potential use, of the photodynamic approach in this area, mainly with reference to tropical diseases having current ‘neglected’ status according to the World Health Organisation. © 2016 The Authors. Coloration Technology © 2016 Society of Dyers and Colourists

Item Type: Article
Uncontrolled Keywords: 0904 Chemical Engineering, 0912 Materials Engineering
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Wiley
Date Deposited: 20 Jan 2017 09:36
Last Modified: 12 Sep 2017 00:49
DOI or Identification number: 10.1111/cote.12259
URI: http://researchonline.ljmu.ac.uk/id/eprint/5322

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