Casey, DR and Charalambous, K and Gee, A and Law, RV and Ces, O (2014) Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature. Interface, 11 (94).
Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature..pdf - Published Version
Small-molecule amphiphilic species such as many drug molecules frequently exhibit low-to-negligible aqueous solubility, and generally have no identified transport proteins assisting their distribution, yet are able to rapidly penetrate significant distances into patient tissue and even cross the blood-brain barrier. Previous work has identified a mechanism of translocation driven by acid-catalysed lipid hydrolysis of biological membranes, a process which is catalysed by the presence of cationic amphiphilic drug molecules. In this study, the interactions of raclopride, a model amphiphilic drug, were investigated with mixtures of biologically relevant lipids across a range of compositions, revealing the influence of the chain-melting temperature of the lipids upon the rate of acyl hydrolysis.
|Uncontrolled Keywords:||MD Multidisciplinary|
|Subjects:||Q Science > QD Chemistry|
|Publisher:||Royal Society Publishing|
|Date Deposited:||06 Mar 2015 10:44|
|Last Modified:||06 Mar 2015 10:44|
|DOI or Identification number:||10.1098/rsif.2013.1062|
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