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Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature.

Casey, DR and Charalambous, K and Gee, A and Law, RV and Ces, O (2014) Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature. Interface, 11 (94).

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Abstract

Small-molecule amphiphilic species such as many drug molecules frequently exhibit low-to-negligible aqueous solubility, and generally have no identified transport proteins assisting their distribution, yet are able to rapidly penetrate significant distances into patient tissue and even cross the blood-brain barrier. Previous work has identified a mechanism of translocation driven by acid-catalysed lipid hydrolysis of biological membranes, a process which is catalysed by the presence of cationic amphiphilic drug molecules. In this study, the interactions of raclopride, a model amphiphilic drug, were investigated with mixtures of biologically relevant lipids across a range of compositions, revealing the influence of the chain-melting temperature of the lipids upon the rate of acyl hydrolysis.

Item Type: Article
Uncontrolled Keywords: MD Multidisciplinary
Subjects: Q Science > QD Chemistry
Divisions: Built Environment
Publisher: Royal Society Publishing
Related URLs:
Date Deposited: 06 Mar 2015 10:44
Last Modified: 06 Mar 2015 10:44
DOI or Identification number: 10.1098/rsif.2013.1062
URI: http://researchonline.ljmu.ac.uk/id/eprint/535

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