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Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida.

Zhu, J-Y and Zhang, C-Y and Dai, J-J and Rahman, K and Zhang, H (2017) Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida. Natural Product Research. ISSN 1478-6419

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Abstract

Chemical investigation of the Jatropha multifida has led to the isolation of nine diterpenoids (1-9), including a new jatromulone A, four podocarpane diterpenoids (2-5), two lathyrane-type diterpenoids (6 and 7) and two dinorditerpenoids (8 and 9). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1 were determined by CD analysis. All of the diterpenoids were screened for inhibitory activity against thioredoxin reductase (TrxR), which is a potential target for cancer chemotherapy with redox balance and antioxidant functions. Compounds 6 and 7 exhibited stronger activity (IC50: 23.4 and 10.6 μM, respectively) than the positive control, curcumin (IC50 = 25.0 μM). Compounds 2-9 were isolated from J. multifida for the first time.

Item Type: Article
Additional Information: “This is an Accepted Manuscript of an article published by Taylor & Francis in Natural Product Research on 10th March 2017, available online: http://www.tandfonline.com/10.1080/14786419.2017.1297441
Uncontrolled Keywords: MD Multidisciplinary
Subjects: Q Science > QD Chemistry
Q Science > QK Botany
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Taylor & Francis
Related URLs:
Date Deposited: 24 Mar 2017 12:31
Last Modified: 24 Mar 2017 12:31
DOI or Identification number: 10.1080/14786419.2017.1297441
URI: http://researchonline.ljmu.ac.uk/id/eprint/6080

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