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Identification of pyrolysis products of the new psychoactive substance 2-amino-1-(4-bromo-2,5- dimethoxyphenyl)ethan-1-one (bk-2C-B) and its iodo analog bk-2C-I

Texter, KB and Waymach, R and Kavanagh, PV and O’Brien, JE and Talbot, B and Brandt, SD and Gardner, EA (2017) Identification of pyrolysis products of the new psychoactive substance 2-amino-1-(4-bromo-2,5- dimethoxyphenyl)ethan-1-one (bk-2C-B) and its iodo analog bk-2C-I. Drug Testing and Analysis. ISSN 1942-7611

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Abstract

2-Amino-1-(4-bromo-2,5-dimethoxyphenyl)ethanone hydrochloride (bk-2C-B) has recently emerged as a new psychoactive substance (NPS). It is most commonly consumed orally although there are indications that it might also be ingested by inhalation or ‘smoking’. Information about the stability of bk-2C-B when exposed to heat is unavailable and the potential for pyrolytic degradation and formation of unknown substances available for inhalation prompted an investigation using a simulated ‘meth pipe’ scenario. Twelve products following pyrolysis of bk- 2C-B were detected and verified by organic synthesis of the corresponding standards. In addition, 2-amino-1-(4-iodo-2,5-dimethoxyphenyl)ethanone hydrochloride (bk-2C-I) has been characterized for the first time and subjected to pyrolysis as well. Similar products were formed, which indicated that the replacement of the bromo with the iodo substituent did not affect the pyrolysis pattern under the conditions used. Two additional products were detected in the bk-2C- I pyrolates, namely 1-(2,5-dimethoxyphenyl)-ethanone and 1-iodo-4-ethenyl-5-methoxyphenol. The potential ingestion of pyrolysis products with unknown toxicity adds an element of concern.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Texter, K. B., Waymach, R., Kavanagh, P. V., O'Brien, J. E., Talbot, B., Brandt, S. D., and Gardner, E. A. (2017) Identification of pyrolysis products of the new psychoactive substance 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethanone hydrochloride (bk-2C-B) and its iodo analog bk-2C-I. Drug Test. Analysis, doi: 10.1002/dta.2200., which has been published in final form at http://dx.doi.org/10.1002/dta.2200 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords: 0301 Analytical Chemistry, 1115 Pharmacology And Pharmaceutical Sciences
Subjects: Q Science > QD Chemistry
R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Wiley
Date Deposited: 28 Mar 2017 09:20
Last Modified: 06 Sep 2017 22:57
DOI or Identification number: 10.1002/dta.2200
URI: http://researchonline.ljmu.ac.uk/id/eprint/6130

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