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Reproducibility of cutaneous vascular conductance responses to slow local heating assessed using 7-laser array probes.

Dawson, EA and Low, DA and Meeuwis, IH and Kerstens, FG and Atkinson, CL and Cable, NT and Green, DJ and Thijssen, DHJ (2015) Reproducibility of cutaneous vascular conductance responses to slow local heating assessed using 7-laser array probes. Microcirculation, 22 (4). pp. 276-284. ISSN 1073-9688

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Abstract

OBJECTIVE: Gradual local heating of the skin induces a largely nitric oxide(NO)-mediated vasodilatation. However, use of this assessment of microvascular health is limited because little is known about its reproducibility. METHODS: Healthy volunteers (n=9) reported twice to the laboratory. Cutaneous vascular conductance (CVC), derived from laser Doppler flux and mean arterial pressure, was examined in response to a standardised local heating protocol (0.5°C per 150s from 33-42°C, followed by 20-minutes at 44°C). Skin responses were examined at two locations on the forearm (between-site). Heating was repeated after a break of 24-72 hours (between-day). Reproducibility of skin-responses at 33-42°C is presented for absolute CVC and relative CVC-responses corrected for maximal CVC at 44°C (%CVCmax ). RESULTS: Between-day reproducibility of baseline CVC and %CVCmax for both sites was relatively poor (22-30%). At 42°C, CVC and %CVCmax responses showed less variation (9-19%), whilst absolute CVC-responses at 44°C were 14-17%. Between-day variation for %CVCmax increased when using data from site 1 on day 1, but site 2 on the subsequent day (25%). CONCLUSION: Day-to-day reproducibility of baseline laser Doppler-derived skin perfusion responses is poor, but acceptable when absolute and relative skin perfusion to a local gradual heating protocol is utilised and site-to-site variation is minimised. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This is the accepted version of the following article: "Reproducibility of cutaneous vascular conductance responses to slow local heating assessed using 7-laser array probes", which has been published in final form in Microcirculation at http://dx.doi.org/10.1111/micc.12196
Uncontrolled Keywords: 11 Medical And Health Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 13 Mar 2015 14:50
Last Modified: 23 Feb 2016 00:50
DOI or Identification number: 10.1111/micc.12196
URI: http://researchonline.ljmu.ac.uk/id/eprint/714

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