Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Delayed plastic responses to anodal tDCS in older adults

Fujiyama, H, Hyde, J, Hinder, MR, Kim, S-J, McCormack, GH, Vickers, JC and Summers, JJ (2014) Delayed plastic responses to anodal tDCS in older adults. Frontiers in Aging Neuroscience, 6. ISSN 1663-4365

Delayed plastic responses to anodal tDCS in older adults.pdf - Published Version
Available under License Creative Commons Attribution.

Download (616kB) | Preview


Despite the abundance of research reporting the neurophysiological and behavioral effects of transcranial direct current stimulation (tDCS) in healthy young adults and clinical populations, the extent of potential neuroplastic changes induced by tDCS in healthy older adults is not well understood. The present study compared the extent and time course of anodal tDCS-induced plastic changes in primary motor cortex (M1) in young and older adults. Furthermore, as it has been suggested that neuroplasticity and associated learning depends on the brain-derived neurotrophic factor (BDNF) gene polymorphisms, we also assessed the impact of BDNF polymorphism on these effects. Corticospinal excitability was examined using transcranial magnetic stimulation before and following (0, 10, 20, 30 min) anodal tDCS (30 min, 1 mA) or sham in young and older adults. While the overall extent of increases in corticospinal excitability induced by anodal tDCS did not vary reliably between young and older adults, older adults exhibited a delayed response; the largest increase in corticospinal excitability occurred 30 min following stimulation for older adults, but immediately post-stimulation for the young group. BDNF genotype did not result in significant differences in the observed excitability increases for either age group. The present study suggests that tDCS-induced plastic changes are delayed as a result of healthy aging, but that the overall efficacy of the plasticity mechanism remains unaffected.

Item Type: Article
Additional Information: Fujiyama H, Hyde J, Hinder MR, Kim S-J, McCormack GH, Vickers JC and Summers JJ (2014) Delayed plastic responses to anodal tDCS in older adults. Front. Aging Neurosci. 6:115. doi: 10.3389/fnagi.2014.00115
Uncontrolled Keywords: Science & Technology; Life Sciences & Biomedicine; Geriatrics & Gerontology; Neurosciences; Neurosciences & Neurology; aging; plasticity; transcranial direct current stimulation; transcranial magnetic stimulation; brain-derived neurotrophic factor; DIRECT-CURRENT STIMULATION; HUMAN MOTOR CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; PHYSICAL-ACTIVITY QUESTIONNAIRE; PAIRED ASSOCIATIVE STIMULATION; NONINVASIVE BRAIN-STIMULATION; THETA-BURST-STIMULATION; INTERINDIVIDUAL VARIABILITY; CORTICAL PLASTICITY; CORTICOSPINAL PROJECTIONS
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Sport & Exercise Sciences
Publisher: Frontiers Media
Related URLs:
Date Deposited: 09 Mar 2018 10:05
Last Modified: 09 Mar 2018 10:05
DOI or Identification number: 10.3389/fnagi.2014.00115
URI: http://researchonline.ljmu.ac.uk/id/eprint/8238

Actions (login required)

View Item View Item