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Zanthoamides G-I: Three new alkamides from Zanthoxylum zanthoxyloides

Guetchueng, S, Nahar, L, Ritchie, KJ, Ismail, FMD, Evans, AR and Sarker, SD Zanthoamides G-I: Three new alkamides from Zanthoxylum zanthoxyloides. Phytochemistry Letters. ISSN 1874-3900 (Accepted)

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Abstract

Three new alkamides, zanthoamides G-I (1-3), together with ten known compounds, araliopsine, skimmianine, N-methylplatydesminium cation, isoplatydesmine, myrtopsine, atanine, N-methylatanine, sesamin, hesperetin and hesperidin, were isolated from the fruits of Zanthoxylum zanthoxyloides. Their structures were elucidated by spectroscopic means. All isolated compounds were assessed for their cytotoxicity against A549, MCF7, PC3 and PNT2 cell lines. Among the alkamides, only zanthoamide G (1) showed low level of cytotoxicity against MCF7 cells.

Item Type: Article
Uncontrolled Keywords: 0304 Medicinal And Biomolecular Chemistry, 0607 Plant Biology, 1115 Pharmacology And Pharmaceutical Sciences
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 23 May 2018 08:38
Last Modified: 23 May 2018 08:38
URI: http://researchonline.ljmu.ac.uk/id/eprint/8699

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