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New tetracyclic triterpenoids from Jatropha gossypiifolia induce cell-cycle arrest and apoptosis in RKO cells.

Zhang, C-Y, Pan, R-R, Zhang, X-D, Zhou, Y, Ye, Y, Xia, J, Rahman, K, Zhang, H and Zhu, J-Y (2018) New tetracyclic triterpenoids from Jatropha gossypiifolia induce cell-cycle arrest and apoptosis in RKO cells. Fitoterapia, 130. pp. 145-151. ISSN 0367-326X

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New tetracyclic triterpenoids from Jatropha gossypiifolia induce cell-cycle arrest and apoptosis in RKO cells..pdf - Accepted Version
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Abstract

Four new tetracyclic-type triterpenoids, jatrogossols A - D (1-4), along with 5 known analogues (5-9), were isolated from the ethanol extract of the branches and leaves of Jatropha gossypiifolia. The absolute configurations of 1-4 were defined by using a combination of electronic circular dichroism data analysis and single-crystal X-ray diffraction data. The cytotoxicities of the triterpenoids were evaluated using RKO and HepG2 human cancer cell lines. Compound 8 was cytotoxic against RKO colon cancer cells with an IC50 value of 12.5 μM. The morphological features of apoptosis were evaluated in 8-treated RKO cells. Compound 8 effectively induced apoptosis of RKO, which was associated with G1 or S phase cell cycle arrest. Flow cytometric analysis showed that treatment with 8 significantly induced RKO cell apoptosis in a dose-dependent manner.

Item Type: Article
Uncontrolled Keywords: 0607 Plant Biology, 1104 Complementary And Alternative Medicine
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
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Date Deposited: 26 Sep 2018 10:31
Last Modified: 29 Sep 2018 05:12
DOI or Identification number: 10.1016/j.fitote.2018.08.027
URI: http://researchonline.ljmu.ac.uk/id/eprint/9333

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