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Machine Learning Approaches and Web-Based System to the Application of Disease Modifying Therapy for Sickle Cell

Khalaf, MI (2018) Machine Learning Approaches and Web-Based System to the Application of Disease Modifying Therapy for Sickle Cell. Doctoral thesis, Liverpool John Moores University.

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Abstract

Sickle cell disease (SCD) is a common serious genetic disease, which has a severe impact due to red blood cell (RBCs) abnormality. According to the World Health Organisation, 7 million newborn babies each year suffer either from the congenital anomaly or from an inherited disease, primarily from thalassemia and sickle cell disease. In the case of SCD, recent research has shown the beneficial effects of a drug called hydroxyurea/hydroxycarbamide in modifying the disease phenotype. The clinical management of this disease-modifying therapy is difficult and time consuming for clinical staff. This includes finding an optimal classifier that can help to solve the issues with missing values, multi-class datasets, and features selection. For the classification and discriminant analysis of SCD datasets, 7 classifiers based on machine learning models are selected representing linear and non-linear methods. After running these classifiers with a single model, the results revealed that a single classifier has provided us with effective outcomes in terms of the classification performance evaluation metric. In order to produce such an optimal outcome, this research proposed and designed combined classifiers (ensemble classifiers) among the neural network’s models, the random forest classifier, and the K-nearest neighbour classifier. In this aspect, combining the levenberg-marquardt algorithm, the voted perceptron classifier, the radial basis neural classifier, and random forest classifier obtain the highest rate of performance and accuracy. This ensemble classifier receives better results during the training set and testing set process. Recent technology advances based on smart devices have improved the medical facilities and become increasingly popular in association with real-time health monitoring and remote/personal health-care. The web-based system developed under the supervision of the haematology specialist at the Alder Hey Children’s Hospital in order to produce such an effective and useful system for both patients and clinicians. To sum up, the simulation experiment concludes that using machine learning and the web-based system platforms represents an alternative procedure that could assist healthcare professionals, particularly for the specialist nurse and junior doctor to improve the quality of care with sickle cell disorder.

Item Type: Thesis (Doctoral)
Uncontrolled Keywords: Machine Learning algorithms; data science; Web-based system
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Divisions: Computer Science
Date Deposited: 12 Oct 2018 11:06
Last Modified: 12 Oct 2018 11:11
DOI or Identification number: 10.24377/researchonline.ljmu.ac.uk.00009470
Supervisors: Hussain, A, Al-Jumeily, D and Shamsa, TB
URI: http://researchonline.ljmu.ac.uk/id/eprint/9470

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