Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Functional Electrical Stimulation Leads to Increased Volume of the Aged Thyroarytenoid Muscle.

Gugatschka, M, Jarvis, JC, Perkins, JD, Bubalo, V, Wiederstein-Grasser, I, Lanmüller, H, Gerstenberger, C and Karbiener, M (2018) Functional Electrical Stimulation Leads to Increased Volume of the Aged Thyroarytenoid Muscle. Laryngoscope. ISSN 1531-4995

[img]
Preview
Text
graz_ms_accepted.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial.

Download (544kB) | Preview

Abstract

OBJECTIVES/HYPOTHESIS: To reverse sarcopenia and increase the volumes of atrophied laryngeal muscles by functional electrical stimulation (FES) using a minimal invasive surgical procedure in an aged ovine model. STUDY DESIGN: Prospective animal study. METHODS: A stimulation electrode was placed unilaterally near the terminal adduction branch of the recurrent laryngeal nerve (RLN) adjacent to the right cricothyroid joint. The electrode was connected to an implant located subcutaneously at the neck region. Predesigned training patterns were automatically delivered by a bidirectional radio frequency link using a programming device and were repeated automatically by the implant every other day over 11 weeks in the awake animal. Outcome parameters comprised volumetric measurements based on three-dimensional reconstructions of the entire thyroarytenoid muscle (TAM), as well as gene expression analyses. RESULTS: We found significant increases of the volumes of the stimulated TAM of 11% and the TAM diameter at the midmembranous parts of the vocal folds of nearly 40%. Based on gene expression, we did not detect a shift of muscle fiber composition. CONCLUSIONS: FES of the terminal branches of the RLN is a secure and effective way to reverse the effects of age-related TAM atrophy and to increase volumes of atrophied muscles. LEVEL OF EVIDENCE: NA Laryngoscope, 2018.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Gugatschka et al.(2018): Electrical Stimulation of Laryngeal Muscles, Laryngoscope, which has been published in final form at https://doi.org/10.1002/lary.27342. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Uncontrolled Keywords: 1103 Clinical Sciences
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 21 Dec 2018 11:54
Last Modified: 21 Dec 2018 15:57
DOI or Identification number: 10.1002/lary.27342
URI: http://researchonline.ljmu.ac.uk/id/eprint/9869

Actions (login required)

View Item View Item