Wang, S J, Wang, X H, Dai, Y Y, Ma, M H, Rahman, K, Nian, H and Zhang, H (2019) Prunella vulgaris: A comprehensive review of chemical constituents, pharmacological effects and clinical applications. Current Pharmaceutical Design. ISSN 1381-6128

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Abstract

Prunella vulgaris (PV) is a perennial herb belonging to the Labiate family and is widely distributed in northeastern Asian countries such as Korea, Japan, and China. It is reported to display diverse biological activities including anti-microbial, anti-cancer, and anti-inflammation as determined by in vitro or in vivo studies. So far, about 200 compounds have been isolated from PV plant and majority of these have been characterized mainly as triterpenoids, sterols and flavonoids, followed by coumarins, phenylpropanoids, polysaccharides and volatile oils. This review summarizes and analyzes the current knowledge on the chemical constituents, pharmacological activities, mechanisms of action and clinical applications of the PV plant including its potential as a future medicinal plant. Although some of the chemical constituents of the PV plant and their mechanism of action have been investigated the biological activities of many of these remain unknown and further clinical trials are required to further enhance its reputation as a medicinal plant.

Item Type:	Article
Uncontrolled Keywords:	1115 Pharmacology and Pharmaceutical Sciences
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Bentham Science Publishers
Related URLs:	https://www.ncbi.nlm.nih.gov/pubmed/30864498
Date Deposited:	22 Mar 2019 11:56
Last Modified:	04 Sep 2021 09:36
DOI or ID number:	10.2174/1381612825666190313121608
URI:	https://researchonline.ljmu.ac.uk/id/eprint/10383

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