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Predicting Early Mild Cognitive Impairment With Free Recall: The Primacy of Primacy.

Talamonti, D, Koscik, R, Johnson, S and Bruno, D (2019) Predicting Early Mild Cognitive Impairment With Free Recall: The Primacy of Primacy. Archives of Clinical Neuropsychology. ISSN 1873-5843

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Abstract

OBJECTIVES: Serial position effects have been found to discriminate between normal and pathological aging, and to predict conversion from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD). Different scoring methods have been used to estimate the accuracy of these predictions. In the current study, we investigated delayed primacy as predictor of progression to early MCI over established diagnostic memory methods. We also compared three serial position methods (regional, standard and delayed scores) to determine which measure is the most sensitive in differentiating between individuals who develop early MCI from a baseline of cognitively intact older adults. METHOD: Data were analyzed with binary logistic regression and with receiver-operating characteristic (ROC). Baseline serial position scores were collected using the Rey's Auditory Verbal Learning Test and used to predict conversion to early MCI. The diagnosis of early MCI was obtained through statistical algorithm and consequent consensus conference. One hundred and ninety-one participants were included in the analyses. All participants were aged 60 or above and cognitively intact at baseline. RESULTS: The binary logistic regression showed that delayed primacy was the only predictor of conversion to early MCI, when compared to total and delayed recall. ROC curves showed that delayed primacy was still the most sensitive predictor of progression to early MCI when compared to other serial position measures. CONCLUSIONS: These findings are consistent with previous studies and support the hypothesis that delayed primacy may be a useful cognitive marker of early detection of neurodegeneration.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Archives of Clinical Neuropsychology following peer review. The version of record Deborah Talamonti, Rebecca Koscik, Sterling Johnson, Davide Bruno, Predicting Early Mild Cognitive Impairment With Free Recall: The Primacy of Primacy, Archives of Clinical Neuropsychology, is available online at: https://doi.org/10.1093/arclin/acz013
Uncontrolled Keywords: 1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Natural Sciences and Psychology
Publisher: Oxford University Press
Related URLs:
Date Deposited: 26 Apr 2019 08:54
Last Modified: 26 Apr 2019 09:13
DOI or Identification number: 10.1093/arclin/acz013
URI: http://researchonline.ljmu.ac.uk/id/eprint/10599

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