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Al Groshi, A, Jasim, HA, Evans, AR, Ismail, FMD, Dempster, NM, Nahar, L and Sarker, SD (2019) Growth inhibitory activity of biflavonoids and diterpenoids from the leaves of the Libyan Juniperus phoenicea against human cancer cells. Phytotherapy Research, 33 (8). pp. 2075-2082. ISSN 1099-1573
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Growth inhibitory activity of biflavonoids and diterpenoids from the leaves of the Libyan Juniperus phoenicea against human cancer cells.pdf - Accepted Version Download (1MB) | Preview |
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Abstract
Three biflavonoids [cupressuflavone (1), amentoflavone (2)and sumaflavone (3)], four diterpenoids [13-epi-cupressic acid (4), imbricatholic acid (5), 3-hydroxy-sandaracopimaric acid (6)and dehydroabietic acid (7)]and onelignan [β-peltatin methyl ether (8)],were isolated from the cytotoxicfractions of the extracts of the leaves of the Libyan Juniperus phoeniceaL. The structures of these compounds were elucidated by spectroscopic means.Cytotoxicity of the compounds 1-6were assessedagainst the human lung cancer cell lineA549 using the MTT assay. Compounds 1and 3showed cytotoxicityagainst the A549cells(IC50= 65 µMand 77 µM, respectively), whereas, compound 2did not show any activity. Diterpenes4-6exhibited weak cytotoxicity against the A549 cells with the IC50values of 159 µM, 263 µMand 223 µM, respectively. The cytotoxicity of each compound was compared with the anticancer drug,etoposide (IC50=61 µM).Cupressuflavone (1)wasevaluatedalso for cytotoxicity against both the human PC3 cancer cell lineand the normal prostatecell line (PNT2), and this compoundrevealed a high degreeof cytotoxic selectivity towards the prostate cancer cells (PC3), with IC50value of 19.9 µM, without any evidence of cytotoxicity towards the normal prostatecell line(PNT2).
| Item Type: | Article |
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| Additional Information: | This is the peer reviewed version of the following article: Al Groshi, A, Jasim, HA, Evans, AR, et al. Growth inhibitory activity of biflavonoids and diterpenoids from the leaves of the Libyan Juniperus phoenicea against human cancer cells. Phytotherapy Research. 2019; 33: 2075– 2082., which has been published in final form at https://dx.doi.org/10.1002/ptr.6397. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Uncontrolled Keywords: | 11 Medical and Health Sciences, 03 Chemical Sciences, 06 Biological Sciences |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Wiley |
| Date Deposited: | 02 May 2019 09:18 |
| Last Modified: | 04 Sep 2021 09:28 |
| DOI or ID number: | 10.1002/ptr.6397 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/10627 |
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