Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Fluctuation in Shear Rate, with Unaltered Mean Shear Rate, Improves Brachial Artery Flow-Mediated Dilation in Healthy, Young Men.

Holder, SM, Dawson, EA, Brislane, Á, Hisdal, J, Green, DJ and Thijssen, DHJ (2019) Fluctuation in Shear Rate, with Unaltered Mean Shear Rate, Improves Brachial Artery Flow-Mediated Dilation in Healthy, Young Men. Journal of Applied Physiology. ISSN 8750-7587

[img]
Preview
Text
JAP_FluSh rebuttal_symplectic.pdf - Accepted Version

Download (485kB) | Preview

Abstract

AIM: Increase in mean shear stress represents an important and potent hemodynamic stimulus to improve conduit artery endothelial function in humans. No previous study has examined whether fluctuations in shear rate patterns, without altering mean shear stress, impacts conduit artery endothelial function. This study examined the hypothesis that 30-minutes exposure to fluctuations in shear rate patterns, in the presence of unaltered mean shear rate, improves brachial artery flow-mediated dilation. METHODS: Fifteen healthy males (27.3±5.0 years) completed the study. Bilateral brachial artery flow-mediated dilation was assessed before and after unilateral exposure to 30-minutes of intermittent negative pressure (10seconds -40mmHg, 7seconds 0mmHg) to induce fluctuation in shear rate, whilst the contra-lateral arm was exposed to a resting period. RESULTS: Negative pressure significantly increased shear rate, followed by a decrease in shear rate upon pressure release (both P<0.001). Across the 30-minute intervention, mean shear rate was not different compared to baseline (P=0.458). A linear mixed model revealed a significant effect of time was observed for flow-mediated dilation (P=0.029), with exploratory post-hoc analysis showing an increase in the intervention arm (∆FMD +2.0%, P=0.008), but not in the contra-lateral control arm (∆FMD +0.5%, P=0.664). However, there was no effect for arm (P=0.619) or interaction effect (P=0.096). CONCLUSION: In conclusion, we found that fluctuations in shear patterns, with unaltered mean shear, improves brachial artery flow-mediated dilation. These novel data suggest that fluctuations in shear pattern, even in the absence of altered mean shear, represents a stimulus to acute change in endothelial function in healthy individuals.

Item Type: Article
Uncontrolled Keywords: 06 Biological Sciences, 11 Medical and Health Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American Physiological Society
Related URLs:
Date Deposited: 10 May 2019 09:16
Last Modified: 04 Sep 2021 09:26
DOI or ID number: 10.1152/japplphysiol.00009.2019
URI: https://researchonline.ljmu.ac.uk/id/eprint/10657
View Item View Item