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The effects of ecstasy' (MDMA) on visuospatial memory performance: findings from a systematic review with meta-analyses

Murphy, PN, Bruno, R, Ryland, I, Wareing, M, Fisk, JE, Montgomery, C and Hilton, J (2012) The effects of ecstasy' (MDMA) on visuospatial memory performance: findings from a systematic review with meta-analyses. Human Psychopharmacology: Clinical and Experimental, 27 (2). pp. 113-138. ISSN 0885-6222

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To review, with meta-analyses where appropriate, performance differences between ecstasy (3,4-methylenedioxymethamphetamine) users and non-users on a wider range of visuospatial tasks than previously reviewed. Such tasks have been shown to draw upon working memory executive resources. Abstract databases were searched using the United Kingdom National Health Service Evidence Health Information Resource. Inclusion criteria were publication in English language peer-reviewed journals and the reporting of new findings regarding human ecstasy-users' performance on visuospatial tasks. Data extracted included specific task requirements to provide a basis for meta-analyses for categories of tasks with similar requirements. Fifty-two studies were identified for review, although not all were suitable for meta-analysis. Significant weighted mean effect sizes indicating poorer performance by ecstasy users compared with matched controls were found for tasks requiring recall of spatial stimulus elements, recognition of figures and production/reproduction of figures. There was no evidence of a linear relationship between estimated ecstasy consumption and effect sizes. Given the networked nature of processing for spatial and non-spatial visual information, future scanning and imaging studies should focus on brain activation differences between ecstasy users and non-users in the context of specific tasks to facilitate identification of loci of potentially compromised activity in users.

Keywords: ecstasy (MDMA); visuospatial; memory;

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Murphy, P. N., Bruno, R., Ryland, I., Wareing, M., Fisk, J. E., Montgomery, C. and Hilton, J. (2012), The effects of ‘ecstasy’ (MDMA) on visuospatial memory performance: findings from a systematic review with meta-analyses. Hum. Psychopharmacol. Clin. Exp., 27: 113–138, which has been published in final form at http://dx.doi.org/10.1002/hup.1270. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences, 1701 Psychology, 1702 Cognitive Science
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Natural Sciences & Psychology (closed 31 Aug 19)
Publisher: Wiley
Related URLs:
Date Deposited: 15 May 2015 09:18
Last Modified: 04 Sep 2021 14:24
DOI or ID number: 10.1002/hup.1270
URI: https://researchonline.ljmu.ac.uk/id/eprint/1085
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