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Diverse Pharmacological Activities and Potential Medicinal Benefits of Geniposide

Zhou, Y-X, Zhang, R-Q, Rahman, K, Cao, Z-X, Zhang, H and Peng, C (2019) Diverse Pharmacological Activities and Potential Medicinal Benefits of Geniposide. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. ISSN 1741-427X

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Abstract

Geniposide is a well-known iridoid glycoside compound and is an essential component of a wide variety of traditional phytomedicines, for example, Gardenia jasminoides Elli (Zhizi in Chinese), Eucommia ulmoides Oliv. (Duzhong in Chinese), Rehmannia glutinosa Libosch. (Dihuang in Chinese), and Achyranthes bidentata Bl. (Niuxi in Chinese). It is also the main bioactive component of Gardeniae Fructus, the dried ripe fruit of Gardenia jasminoides Ellis. Increasing pharmacological evidence supports multiple medicinal properties of geniposide including neuroprotective, antidiabetic, hepatoprotective, anti-inflammatory, analgesic, antidepressant-like, cardioprotective, antioxidant, immune-regulatory, antithrombotic, and antitumoral effects. It has been proposed that geniposide may be a drug or lead compound for the prophylaxis and treatment of several diseases, such as Alzheimer’s disease, Parkinson’s disease, diabetes and diabetic complications, ischemia and reperfusion injury, and hepatic disorders. The aim of the present review is to give a comprehensive summary and analysis of the pharmacological properties of geniposide, supporting its use as a medicinal agent.

Item Type: Article
Uncontrolled Keywords: 1104 Complementary and Alternative Medicine
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Pharmacy & Biomolecular Sciences
Publisher: HINDAWI LTD
Related URLs:
Date Deposited: 26 Jun 2019 08:59
Last Modified: 26 Jun 2019 09:00
DOI or Identification number: 10.1155/2019/4925682
URI: http://researchonline.ljmu.ac.uk/id/eprint/10934

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