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Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: Mega-analytic findings from a large multi-site cohort

Tozzi, L, Garczarek, L, Janowitz, D, Stein, DJ, Wittfeld, K, Dobrowolny, H, Lagopoulos, J, Hatton, SN, Hickie, IB, Carballedo, A, Brooks, SJ, Vuletic, D, Uhlmann, A, Veer, IM, Walter, H, Bülow, R, Völzke, H, Klinger-König, J, Schnell, K, Schoepf, D , Grotegerd, D, Opel, N, Dannlowski, U, Kugel, H, Schramm, E, Konrad, C, Kircher, T, Jüksel, D, Nenadic, I, Krug, A, Hahn, T, Steinsträter, O, Redlich, R, Zaremba, D, Zurowski, B, Fu, CHY, DIma, D, Cole, J, Grabe, HJ, Connolly, CG, Yang, TT, Ho, TC, Lewinn, KZ, Li, M, Groenewold, NA, Salminen, LE, Walter, M, Simmons, AN, Van Erp, TGM, Jahanshad, N, Baune, BT, Van Der Wee, NJA, Van Tol, MJ, Penninx, BWJH, Hibar, DP, Thompson, PM, Veltman, DJ, Schmaal, L and Frodl, T (2019) Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: Mega-analytic findings from a large multi-site cohort. Psychological Medicine. ISSN 0033-2917

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Abstract

Background. Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.MethodsWithin the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.ResultsCM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.ConclusionsSeverity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind. © 2019 Cambridge University Press.

Item Type: Article
Uncontrolled Keywords: 1701 Psychology, 1117 Public Health and Health Services, 1109 Neurosciences
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Natural Sciences and Psychology
Publisher: Cambridge University Press
Date Deposited: 19 Jul 2019 10:39
Last Modified: 19 Jul 2019 10:45
DOI or Identification number: 10.1017/S003329171900093X
URI: http://researchonline.ljmu.ac.uk/id/eprint/11080

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