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Endoplasmic reticulum stress activates unfolded protein response signaling and mediates inflammation, obesity and cardiac dysfunction: Therapeutic and molecular approach

Amen, OM, Sarker, SD, Ghildyal, R and Arya, A (2019) Endoplasmic reticulum stress activates unfolded protein response signaling and mediates inflammation, obesity and cardiac dysfunction: Therapeutic and molecular approach. Frontiers in Pharmacology. ISSN 1663-9812

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Abstract

Obesity has been implicated as a risk factor for insulin resistance and cardiovascular diseases (CVDs). Although the association between obesity and CVD is a well-established phenomenon, the precise mechanisms remain incompletely understood. This has led to a relative paucity of therapeutic measures for the prevention and treatment of CVD and associated metabolic disorders. Recent studies have shed light on the pivotal role of prolonged endoplasmic reticulum stress (ERS)-initiated activation of the unfolded protein response (UPR), and the ensuing chronic low-grade inflammation, and altered insulin signaling in promoting obesity-compromised cardiovascular system (CVS). In this aspect, potential ways of attenuating ERS-initiated UPR signaling seems a promising avenue for therapeutic interventions. We review intersecting role of obesity-induced ERS, chronic inflammation, insulin resistance, and oxidative stress in the discovery of targeted therapy. Moreover, this review highlights the current progress and strategies on therapeutics being explored in preclinical and clinical research to modulate ERS and UPR signaling.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology and Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Frontiers Media
Date Deposited: 16 Aug 2019 10:02
Last Modified: 10 Sep 2019 09:15
DOI or Identification number: 10.3389/fphar.2019.00977
URI: http://researchonline.ljmu.ac.uk/id/eprint/11220

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