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A new approach to the diagnosis and treatment of atherosclerosis: the era of the liposome

Kiaie, N, Gorabi, AM, Penson, PE, Watts, G, Johnston, TP, Banach, M and Sahebkar, A (2019) A new approach to the diagnosis and treatment of atherosclerosis: the era of the liposome. Drug Discovery Today. ISSN 1359-6446

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Abstract

The consequences of atherosclerotic cardiovascular disease (ASCVD) include myocardial infarction, ischemic stroke, and angina pectoris, which are major causes of mortality and morbidity worldwide. Despite current therapeutic strategies to reduce risk, patients still experience the consequences of ASCVD. Consequently, a current goal is to enhance visualization of early atherosclerotic lesions to improve residual ASCVD risk. The uses of liposomes, in the context of ASCVD, can include as contrast agents for imaging techniques, as well as for the delivery of antiatherosclerotic drugs, genes, and cells to established sites of plaque. Additionally, liposomes have a role as vaccine adjuvants against mediators of atherosclerosis. Here. we review the scientific and clinical evidence relating to the use of liposomes in the diagnosis and management of ASCVD.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology and Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 17 Sep 2019 08:24
Last Modified: 17 Sep 2019 08:24
DOI or Identification number: 10.1016/j.drudis.2019.09.005
URI: http://researchonline.ljmu.ac.uk/id/eprint/11337

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