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Osman, NM, Sexton, DW and Saleem, IY (2019) Toxicological assessment of nanoparticle interactions with the pulmonary system. Nanotoxicology. ISSN 1743-5390
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Toxicological assessment of nanoparticle interactions with the pulmonary system..pdf - Accepted Version Download (1MB) | Preview |
Abstract
Nanoparticle(NP)-based materials have breakthrough applications in many fields of life, such as in engineering, communications and textiles industries; food and bioenvironmental applications; medicines and cosmetics, etc. Biomedical applications of NPs are very active areas of research with successful translation to pharmaceutical and clinical uses overcoming both pharmaceutical and clinical challenges. Although the attractiveness and enhanced applications of these NPs stem from their exceptional properties at the nanoscale size, i.e. 1-1000 nm, they exhibit completely different physicochemical profiles and, subsequently, toxicological profiles from their parent bulk materials. Hence, the clinical evaluation and toxicological assessment of NPs interactions within biological systems are continuously evolving to ensure their safety at the nanoscale. The pulmonary system is one of the primary routes of exposure to airborne NPs either intentionally, via aerosolized nanomedicines targeting pulmonary pathologies such as cancer or asthma, or unintentionally, via natural NPs and anthropogenic (man-made) NPs. This review presents the state-of-the-art, contemporary challenges, and knowledge gaps in the toxicological assessment of NPs interactions with the pulmonary system. It highlights the main mechanisms of NP toxicity, factors influencing their toxicity, the different toxicological assessment methods and their drawbacks, and the recent NP regulatory guidelines based on literature collected from the research pool of NPs interactions with lung cell lines, in vivo inhalation studies, and clinical trials.
| Item Type: | Article |
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| Additional Information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Nanotoxicology on 10/09/2019, available online: http://www.tandfonline.com/10.1080/17435390.2019.1661043 |
| Uncontrolled Keywords: | 1007 Nanotechnology |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Taylor & Francis |
| Related URLs: | |
| Date Deposited: | 14 Nov 2019 11:45 |
| Last Modified: | 04 Sep 2021 08:52 |
| DOI or ID number: | 10.1080/17435390.2019.1661043 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/11365 |
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