Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies 4 transmission in African nonhuman primates

Chuma, IS, Roos, C, Atickem, A, Bohm, T, Collins, A, Grillova, L, Hallmaier-Wacker, LK, Kazwala, RR, Keyyu, JD, Lüert, S, Maloueki, U, Oppelt, J, Petrželková, KJ, Piel, AK, Stewart, FA, Smajs, D and Knauf, S Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies 4 transmission in African nonhuman primates. Scientific Reports. ISSN 2045-2322 (Accepted)

[img]
Preview
Text
41598_2019_50779_Author.pdf - Accepted Version

Download (1MB) | Preview

Abstract

In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of nHp origin.

Item Type: Article
Uncontrolled Keywords: 0601 Biochemistry and Cell Biology, 0299 Other Physical Sciences
Subjects: Q Science > QL Zoology
Divisions: Biological & Environmental Sciences (new Sep 19)
Publisher: Nature Publishing Group
Date Deposited: 23 Sep 2019 09:07
Last Modified: 23 Sep 2019 09:15
URI: http://researchonline.ljmu.ac.uk/id/eprint/11370

Actions (login required)

View Item View Item