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Role of blood pressure in mediating carotid artery dilation in response to sympathetic stimulation in healthy, middle-aged individuals

Peace, A, Pinna, V, Timmen, F, Speretta, G, Jones, H, Lotto, RR, Jones, IS and Thijssen, DHJ (2019) Role of blood pressure in mediating carotid artery dilation in response to sympathetic stimulation in healthy, middle-aged individuals. American Journal of Hypertension. ISSN 0895-7061

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Abstract

Objectives: Carotid artery diameter responses to sympathetic stimulation, i.e., carotid artery reactivity (CAR), represent a novel test of vascular health and relates to cardiovascular disease (CVD)/risk. This study aims to understand the relationship between the increase in blood pressure and carotid artery diameter response during the CAR-test in healthy, middle-aged men.
Methods: Sample consisted of 40 normotensive men (aged 31–59 years) with no history of CVD of currently taking medication. Noninvasive ultrasound was used to measure carotid artery diameter during the cold pressor test (CPT), with CAR% being calculated as the relative change from baseline (%). Mean arterial pressure (MAP) was measured with beat-to-beat blood pressure recording.
Results: CAR% was 4.4 ± 5.4%, peaking at 92 ± 43 seconds. MAP increased from 88 ± 9 mmHg to 110 ± 15 mmHg, peaked at 112 ± 38 seconds, which was significantly later than the diameter peak (P = 0.04). The correlation between resting MAP and CAR% was weak (r = 0.209 P = 0.197). Tertiles based on resting MAP or MAP-increase revealed no significant differences between groups in subject characteristics including age, body mass index, or CAR% (all P > 0.05). Subgroup analysis of individuals with carotid constriction (n = 6) vs. dilation (n = 34), revealed no significant difference in resting MAP or increase in MAP (P = 0.209 and 0.272, respectively).
Conclusion: Our data suggest that the characteristic increase in MAP during the CPT does not mediate carotid artery vasomotion.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in American Journal of Hypertension following peer review. The version of record Arron Peace, Virginia Pinna, Friso Timmen, Guillherme Speretta, Helen Jones, Robyn Lotto, Ian Jones, Dick Thijssen, Role of Blood Pressure in Mediating Carotid Artery Dilation in Response to Sympathetic Stimulation in Healthy, Middle-Aged Individuals, American Journal of Hypertension, hpz159, is available online at: http://dx.doi.org/10.1093/ajh/hpz159
Uncontrolled Keywords: 1103 Clinical Sciences
Subjects: R Medicine > R Medicine (General)
Divisions: Education
Sports & Exercise Sciences
Publisher: Oxford University Press (OUP)
Date Deposited: 25 Nov 2019 12:20
Last Modified: 25 Nov 2019 12:30
DOI or Identification number: 10.1093/ajh/hpz159
URI: http://researchonline.ljmu.ac.uk/id/eprint/11412

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