Maasakkers, CM, Claassen, JAHR, Gardiner, PA, Olde Rikkert, MGM, Lipnicki, DM, Scarmeas, N, Dardiotis, E, Yannakoulia, M, Anstey, KJ, Cherbuin, N, Haan, MN, Kumagai, S, Narazaki, K, Chen, T, Ng, TP, Gao, Q, Nyunt, MSZ, Crawford, JD, Kochan, NA, Makkar, SR et al, Sachdev, PS, COSMIC Collaborators, , Thijssen, DHJ and Melis, RJF (2019) The Association of Sedentary Behaviour and Cognitive Function in People Without Dementia: A Coordinated Analysis Across Five Cohort Studies from COSMIC. Sports Medicine. ISSN 0112-1642

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Abstract

BACKGROUND: Besides physical activity as a target for dementia prevention, sedentary behaviour is hypothesized to be a potential target in its own right. The rising number of persons with dementia and lack of any effective treatment highlight the urgency to better understand these modifiable risk factors. Therefore, we aimed to investigate whether higher levels of sedentary behaviour are associated with reduced global cognitive functioning and slower cognitive decline in older persons without dementia. METHODS: We used five population cohorts from Greece, Australia, USA, Japan, and Singapore (HELIAD, PATH, SALSA, SGS, and SLAS2) from the Cohort Studies of Memory in an International Consortium. In a coordinated analysis, we assessed the relationship between sedentary behaviour and global cognitive function with the use of linear mixed growth model analysis (mean follow-up range of 2.0-8.1 years). RESULTS: Baseline datasets combined 10,450 older adults without dementia with a mean age range between cohorts of 66.7-75.1 years. After adjusting for multiple covariates, no cross-sectional association between sedentary behaviour and cognition was found in four studies. One association was detected where more sedentary behaviour was cross-sectionally linked to higher cognition levels (SLAS2, B = 0.118 (0.075; 0.160), P < 0.001). Longitudinally, there were no associations between baseline sedentary behaviour and cognitive decline (P > 0.05). CONCLUSIONS: Overall, these results do not suggest an association between total sedentary time and lower global cognition in older persons without dementia at baseline or over time. We hypothesize that specific types of sedentary behaviour may differentially influence cognition which should be investigated further. For now, it is, however, too early to establish undifferentiated sedentary time as a potential effective target for minimizing cognitive decline in older adults without dementia.

Item Type:	Article
Uncontrolled Keywords:	1106 Human Movement and Sports Sciences, 0913 Mechanical Engineering, 1302 Curriculum and Pedagogy
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Publisher:	Springer Verlag
Related URLs:	https://www.ncbi.nlm.nih.gov/pubmed/31529300
Date Deposited:	14 Oct 2019 11:11
Last Modified:	04 Sep 2021 08:49
DOI or ID number:	10.1007/s40279-019-01186-7
URI:	https://researchonline.ljmu.ac.uk/id/eprint/11414

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