Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Commiphora molmol Modulates Glutamate-Nitric Oxide-cGMP and Nrf2/ARE/HO-1 Pathways and Attenuates Oxidative Stress and Hematological Alterations in Hyperammonemic Rats.

Mahmoud, AM, Alqahtani, S, Othman, SI, Germoush, MO, Hussein, OE, Al-Basher, G, Khim, JS, Al-Qaraawi, MA, Al-Harbi, HM, Fadel, A and Allam, AA (2017) Commiphora molmol Modulates Glutamate-Nitric Oxide-cGMP and Nrf2/ARE/HO-1 Pathways and Attenuates Oxidative Stress and Hematological Alterations in Hyperammonemic Rats. Oxidative Medicine and Cellular Longevity, 2017. pp. 1-15. ISSN 1942-0900

[img]
Preview
Text
Commiphora molmol Modulates Glutamate-Nitric Oxide-cGMP and Nrf2AREHO-1 Pathways and Attenuates Oxidative Stress and Hematol.pdf - Published Version
Available under License Creative Commons Attribution.

Download (2MB) | Preview

Abstract

Hyperammonemia is a serious complication of liver disease and may lead to encephalopathy and death. This study investigated the effects of Commiphora molmol resin on oxidative stress, inflammation, and hematological alterations in ammonium chloride- (NH4Cl-) induced hyperammonemic rats, with an emphasis on the glutamate-NO-cGMP and Nrf2/ARE/HO-1 signaling pathways. Rats received NH4Cl and C. molmol for 8 weeks. NH4Cl-induced rats showed significant increase in blood ammonia, liver function markers, and tumor necrosis factor-alpha (TNF-α). Concurrent supplementation of C. molmol significantly decreased circulating ammonia, liver function markers, and TNF-α in hyperammonemic rats. C. molmol suppressed lipid peroxidation and nitric oxide and enhanced the antioxidant defenses in the liver, kidney, and cerebrum of hyperammonemic rats. C. molmol significantly upregulated Nrf2 and HO-1 and decreased glutamine and nitric oxide synthase, soluble guanylate cyclase, and Na+/K+-ATPase expression in the cerebrum of NH4Cl-induced hyperammonemic rats. Hyperammonemia was also associated with hematological and coagulation system alterations. These alterations were reversed by C. molmol. Our findings demonstrated that C. molmol attenuates ammonia-induced liver injury, oxidative stress, inflammation, and hematological alterations. This study points to the modulatory effect of C. molmol on glutamate-NO-cGMP and Nrf2/ARE/HO-1 pathways in hyperammonemia. Therefore, C. molmol might be a promising protective agent against hyperammonemia.

Item Type: Article
Uncontrolled Keywords: 11 Medical and Health Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Sports & Exercise Sciences
Publisher: Hindawi
Related URLs:
Date Deposited: 03 Oct 2019 08:38
Last Modified: 03 Oct 2019 08:38
DOI or Identification number: 10.1155/2017/7369671
URI: http://researchonline.ljmu.ac.uk/id/eprint/11426

Actions (login required)

View Item View Item