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Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites.

Pudjiastuti, P, Puspaningsih, NNT, Siswanto, I, Fanani, MZ, Ariga, YK, Hase, T, Sarker, SD and Nahar, L (2018) Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites. Journal of Parasitology Research, 2018. ISSN 2090-0023

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Abstract

Ferredoxin-NADP+ reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents. Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Stemona sp. and their inhibitory effect on FNRs from Plasmodium falciparum (PfFNR) was investigated. Croomine showed the highest level of inhibition (33.9%) of electron transfer from PfFNR to PfFd, while tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of PfFNR. Docking analysis represented that croomine is located at the middle position of PfFNR and PfFd. Croomine from S. tuberosa appeared to have potential as an antimalarial agent.

Item Type: Article
Uncontrolled Keywords: 1108 Medical Microbiology, 1117 Public Health and Health Services
Subjects: Q Science > QR Microbiology
Q Science > QR Microbiology > QR355 Virology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Hindawi Publishing Company
Related URLs:
Date Deposited: 07 Oct 2019 10:10
Last Modified: 07 Oct 2019 10:15
DOI or Identification number: 10.1155/2018/3469132
URI: http://researchonline.ljmu.ac.uk/id/eprint/11475

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