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Muscle nonshivering thermogenesis in a feral mammal

Nowack, J, Vetter, SG, Stalder, G, Painer, J, Kral, M, Smith, S, Minh, HL, Jurcevic, P, Bieber, C, Arnold, W and Ruf, T (2019) Muscle nonshivering thermogenesis in a feral mammal. Scientific Reports, 9. ISSN 2045-2322

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Abstract

Muscle nonshivering thermogenesis (NST) was recently suggested to play an important role in thermoregulation of species lacking brown adipose tissue (BAT). The mechanism, which is independent of muscle contractions, produces heat based on the activity of an ATPase pump in the sarcoplasmic reticulum (SERCA1a) and is controlled by the protein sarcolipin. To evaluate whether muscle NST could indeed play an important role in thermoregulation in species lacking BAT, we investigated the thermogenic capacities of newborn wild boar piglets. During cold exposure over the first 5 days of life, total heat production was improved while shivering intensity decreased, indicating an increasing contribution of NST. Sampling skeletal muscle tissue for analyses of SERCA activity as well as gene expression of SERCA1a and sarcolipin, we found an age-related increase in all three variables as well as in body temperature. Hence, the improved thermogenesis during the development of wild boars is not due to shivering but explained by the observed increase in SERCA activity. Our results suggest that muscle NST may be the primary mechanism of heat production during cold stress in large mammals lacking BAT, strengthening the hypothesis that muscle NST has likely played an important role in the evolution of endothermy.

Item Type: Article
Uncontrolled Keywords: 0601 Biochemistry and Cell Biology, 0299 Other Physical Sciences
Subjects: Q Science > QL Zoology
Divisions: Biological & Environmental Sciences (new Sep 19)
Publisher: Nature Publishing Group
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Date Deposited: 07 Oct 2019 11:19
Last Modified: 07 Oct 2019 11:30
DOI or Identification number: 10.1038/s41598-019-42756-z
URI: http://researchonline.ljmu.ac.uk/id/eprint/11481

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