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Non-tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia

Edwin, C, Dean, J, Bonnett, L, Phillips, KLE and Keenan, R (2016) Non-tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia. Pediatric Blood and Cancer, 63 (10). pp. 1848-1851. ISSN 1545-5009

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Abstract

Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B-cell acute lymphoblastic leukaemia. Our analysis identified a sub-group (∼30% of patients) with>2.37% CD20 and>6.05% CD7 expression, which had 100% OS, and a sub-group (∼30% of patients) with ≤2.37% CD20 and ≤6.05% CD7 expression at increased risk of treatment failure (66.7% OS, P < 0.05). Immune cell infiltrate at diagnosis may predict treatment response and could provide a means to enhance immediate treatment risk stratification.

Item Type: Article
Uncontrolled Keywords: 1112 Oncology and Carcinogenesis, 1114 Paediatrics and Reproductive Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RJ Pediatrics
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 08 Oct 2019 09:14
Last Modified: 08 Oct 2019 09:15
DOI or Identification number: 10.1002/pbc.26093
URI: http://researchonline.ljmu.ac.uk/id/eprint/11483

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