Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Influence of antimicrobial photodynamic therapy as an adjunctive to scaling and root planing on alveolar bone loss: A systematic review and meta-analysis of animal studies.

Alberton Nuernberg, MA, Janjacomo Miessi, DM, Ivanaga, CA, Bocalon Olivo, M, Ervolino, E, Gouveia Garcia, V, Wainwright, M and Theodoro, LH (2019) Influence of antimicrobial photodynamic therapy as an adjunctive to scaling and root planing on alveolar bone loss: A systematic review and meta-analysis of animal studies. Photodiagnosis and Photodynamic Therapy, 25. pp. 354-363. ISSN 1873-1597

[img]
Preview
Text
Nuernberg et al 2019.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (12MB) | Preview

Abstract

BACKGROUND: The study aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) as adjunctive therapy to scaling and root planing in experimental periodontitis in rats, with or without systemic involvement, by means of histometric analysis of the furcation region. METHODS: Systematic search was done using PubMed/MEDLINE, SCOPUS, EMBASE and ProQuest databases. Quantitative analysis of alveolar bone loss, with subcategories for the experimental periods studied, was performed. The analysis was performed through the mean difference (MD), with 95% confidence intervals (CIs) and according to SYRCLE guidelines. RESULTS: Nine studies were considered eligible. A statistically favorable difference was observed for the use of aPDT in all periods studied in systemically healthy animals at 7 (P < 0.00001; MD: -0.71; 95% CI: [-0.85, -0.58]; I2: 90%), 15 (P < 0.00001; MD: -0.49; 95% CI: [-0.62, -0.37]; I2: 88%), and 30 (P < 0.00001; MD: -0.53; 95% CI: [-0.65, -0.41]; I2: 80%) days postoperatively. The difference was also observed for modified animals at 7 (P < 0.00001; MD: -1.03; 95% CI: [-1.43, -0.62]; I2: 97%), 15 (P < 0.00001; MD: -1.04; 95% CI: [-1.62, -0.46]; I2: 99%), and 30 (P < 0.00001; MD: -0.88; 95% CI: [-1.37, -0.39]; I2: 97%) days postoperatively. CONCLUSION: The adjunctive use of aPDT favored the reduction of alveolar bone loss in experimental periodontitis in rats, and this result was more evident in systemically compromised rats.

Item Type: Article
Uncontrolled Keywords: Alveolar bone loss; Periodontal disease; Photochemotherapy; Systematic review; Alveolar Bone Loss; Animals; Combined Modality Therapy; Dental Scaling; Periodontitis; Photochemotherapy; Photosensitizing Agents; Rats; Root Planing
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Related URLs:
Date Deposited: 14 Oct 2019 09:38
Last Modified: 15 Jan 2020 00:50
DOI or Identification number: 10.1016/j.pdpdt.2019.01.020
URI: http://researchonline.ljmu.ac.uk/id/eprint/11564

Actions (login required)

View Item View Item