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Characterization of the Role of NKA in the Control of Puberty Onset and Gonadotropin Release in the Female Mouse.

León, S, Fergani, C, Talbi, R, Simavli, S, Maguire, CA, Gerutshang, A and Navarro, VM (2019) Characterization of the Role of NKA in the Control of Puberty Onset and Gonadotropin Release in the Female Mouse. Endocrinology, 160 (10). pp. 2453-2463. ISSN 0013-7227

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Abstract

The tachykinin neurokinin B (NKB, Tac2) is critical for proper GnRH release in mammals, however, the role of the other tachykinins, such as substance P (SP) and neurokinin A (NKA) in reproduction, is still not well understood. In this study, we demonstrate that NKA controls the timing of puberty onset (similar to NKB and SP) and stimulates LH release in adulthood through NKB-independent (but kisspeptin-dependent) mechanisms in the presence of sex steroids. Furthermore, this is achieved, at least in part, through the autosynaptic activation of Tac1 neurons, which express NK2R (Tacr2), the receptor for NKA. Conversely, in the absence of sex steroids, as observed in ovariectomy, NKA inhibits LH through a mechanism that requires the presence of functional receptors for NKB and dynorphin (NK3R and KOR, respectively). Moreover, the ability of NKA to modulate LH secretion is absent in Kiss1KO mice, suggesting that its action occurs upstream of Kiss1 neurons. Overall, we demonstrate that NKA signaling is a critical component in the central control of reproduction, by contributing to the indirect regulation of kisspeptin release.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Endocrinology following peer review. The version of record Silvia León, Chrysanthi Fergani, Rajae Talbi, Serap Simavli, Caroline A Maguire, Achi Gerutshang, Víctor M Navarro, Characterization of the Role of NKA in the Control of Puberty Onset and Gonadotropin Release in the Female Mouse, Endocrinology, Volume 160, Issue 10, October 2019, Pages 2453–2463, is available online at: http://dx.doi.org/10.1210/en.2019-00195
Uncontrolled Keywords: 07 Agricultural and Veterinary Sciences, 11 Medical and Health Sciences, 06 Biological Sciences
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Biological & Environmental Sciences (new Sep 19)
Publisher: Oxford University Press (OUP)
Related URLs:
Date Deposited: 15 Oct 2019 11:31
Last Modified: 15 Oct 2019 11:45
DOI or Identification number: 10.1210/en.2019-00195
URI: http://researchonline.ljmu.ac.uk/id/eprint/11578

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