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A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010-2019)

Nahar, L, Onder, A and Sarker, SD A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010-2019). Phytochemical Analysis. ISSN 0958-0344 (Accepted)

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Abstract

Introduction: Organic molecules that bind to cannabinoid receptors are called cannabinoids, and they have similar pharmacological properties like the plant, Cannabis sativa L. Hyphenated liquid chromatography (LC), incorporating high performance liquid chromatography (HPLC) and ultra performance liquid chromatography (UPLC, also known as ultra high performance liquid chromatography, UHPLC), usually coupled to a UV, UV-PDA or MS detector, has become a popular analytical tool for the analysis of naturally occurring cannabinoids in various matrices.
Objective: To review literature on the use of various LC-based analytical methods for the analysis of naturally occurring cannabinoids published since 2010.
Methodology: A comprehensive literature search was performed utilizing several databases, like Web of Knowledge, PubMed and Google Scholar, and other relevant published materials including published books. The keywords used, in various combinations, with cannabinoids being present in all combinations, in the search were Cannabis, hemp, cannabinoids, Cannabis sativa, marijuana, analysis, HPLC, UHPLC, UPLC, quantitative, qualitative and quality control.
Results: Since 2010, several LC methods for the analysis of naturally occurring cannabinoids have been reported. While simple HPLC-UV or HPLC-UV-PDA-based methods were common in cannabinoids analysis, HPLC-MS, HPLC-MS/MS, UPLC (or UHPLC)-UV-PDA, UPLC (or UHPLC)-MS and UPLC (or UHPLC)-MS/MS, were also used frequently. Applications of mathematical and computational models for optimization of different protocols were observed, and pre-analyses included various environmentally friendly extraction protocols.
Conclusions: LC-based analysis of naturally occurring cannabinoids has dominated the cannabinoids analysis during the last ten years, and UPLC and UHPLC methods have been shown to be superior to conventional HPLC methods.

Item Type: Article
Uncontrolled Keywords: 03 Chemical Sciences, 11 Medical and Health Sciences, 06 Biological Sciences
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Wiley
Date Deposited: 18 Nov 2019 10:39
Last Modified: 18 Nov 2019 10:45
URI: http://researchonline.ljmu.ac.uk/id/eprint/11778

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