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Cytotoxic stilbenes and canthinone alkaloids from Brucea antidysenterica (Simaroubaceae)

Makong, YS, Happi, GM, Bavoua, JLD, Wansi, JD, Nahar, L, Waffo, AFK, Martin, C, Sewald, N and Sarker, SD (2019) Cytotoxic stilbenes and canthinone alkaloids from Brucea antidysenterica (Simaroubaceae). Molecules, 24 (23). ISSN 1420-3049 (Accepted)

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Abstract

Phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), as well as ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12) and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identity of the known compounds was further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, as well as the isolated compounds (3–13), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7 and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity.

Item Type: Article
Uncontrolled Keywords: 0305 Organic Chemistry, 0307 Theoretical and Computational Chemistry, 0304 Medicinal and Biomolecular Chemistry
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Pharmacy & Biomolecular Sciences
Publisher: MDPI AG
Date Deposited: 03 Dec 2019 13:34
Last Modified: 03 Dec 2019 13:34
DOI or Identification number: 10.3390/molecules24234412
URI: http://researchonline.ljmu.ac.uk/id/eprint/11830

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