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The impact of acute remote ischaemic preconditioning on cerebrovascular function

Carter, HH, Maxwell, JD, Hellsten, Y, Thompson, A, Thijssen, DHJ and Jones, H (2020) The impact of acute remote ischaemic preconditioning on cerebrovascular function. European Journal of Applied Physiology, 120. pp. 603-612. ISSN 1439-6319

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Purpose: Remote ischaemic preconditioning (RIPC) refers to the protection conferred to tissues and organs via brief periods of ischaemia in a remote vascular territory, including the brain. Recent studies in humans report that RIPC provides neuroprotection against recurrent (ischaemic) stroke. To better understand the ability of RIPC to improve brain health, the present study explored the potential for RIPC to acutely improve cerebrovascular function. Methods: Eleven young healthy (Females n=6, Age; 28.1±3.7yrs) and 9 older individuals (Females n=4, Age 52.5±6.7yrs) at increased risk for stroke (cardiovascular disease risk factors) underwent assessments of cerebrovascular function, assessed by carbon dioxide (CO2) reactivity and cerebral autoregulation during normo- and hypercapnia (5%CO2) following 40mins of bilateral arm RIPC or a sham condition. Squat-to-stand manoeuvres were performed to induce changes in blood pressure to assess cerebral autoregulation (0.10 Hz) and analysed via transfer function. Results: We found no change in middle cerebral artery velocity or blood pressure across 40mins of RIPC. Application of RIPC resulted in no change in CO2 reactivity slopes (sham vs RIPC, 1.97±0.88 vs 2.06±0.69 cm/s/mmHg P=0.61) or parameters of cerebral autoregulation during normocapnia (sham vs RIPC, normalised gain%, 1.27±0.25 vs 1.22±0.35, P=0.46). Conclusion: This study demonstrates that a single bout of RIPC does not influence cerebrovascular function acutely in healthy individuals, or those at increased cardiovascular risk. Given the previously reported protective role of RIPC on stroke recurrence in humans, it is possible that repeated bouts of RIPC may be necessary in order to impart beneficial effects on cerebrovascular function.

Item Type: Article
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences
Subjects: Q Science > QM Human anatomy
Q Science > QP Physiology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Springer Verlag
Date Deposited: 11 Dec 2019 14:38
Last Modified: 13 Jan 2022 14:45
DOI or ID number: 10.1007/s00421-019-04297-1
URI: https://researchonline.ljmu.ac.uk/id/eprint/11889
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