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Spinal signaling of C-fiber mediated pleasant touch in humans.

Marshall, AG, Sharma, ML, Marley, K, Olausson, H and McGlone, FP (2019) Spinal signaling of C-fiber mediated pleasant touch in humans. eLife, 8. ISSN 2050-084X

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Abstract

C-tactile afferents form a distinct channel that encodes pleasant tactile stimulation. Prevailing views indicate they project, as with other unmyelinated afferents, in lamina I-spinothalamic pathways. However, we found that spinothalamic ablation in humans, whilst profoundly impairing pain, temperature and itch, had no effect on pleasant touch perception. Only discriminative touch deficits were seen. These findings preclude privileged C-tactile-lamina I-spinothalamic projections and imply integrated hedonic and discriminative spinal processing from the body.

Item Type: Article
Uncontrolled Keywords: 0601 Biochemistry and Cell Biology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Psychology (new Sep 2019)
Publisher: eLife Sciences Publications Ltd
Related URLs:
Date Deposited: 08 Jan 2020 10:45
Last Modified: 08 Jan 2020 10:45
DOI or Identification number: 10.7554/eLife.51642
URI: http://researchonline.ljmu.ac.uk/id/eprint/11971

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