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Coenzyme Q10 supplementation in non alcoholic liver disease: an overview.

Mantle, D and Hargreaves, IP (2020) Coenzyme Q10 supplementation in non alcoholic liver disease: an overview. Gastrointestinal Nursing, 18 (2). pp. 22-27. ISSN 1479-5248

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in the UK, for which little effective conventional treatment is available. Mitochondrial dysfunction, oxidative stress and inflammation have been implicated in the pathogenesis of NAFLD. This article focuses on the role of the vitamin-like substance coenzyme Q10 (CoQ10) in NAFLD, since CoQ10 plays a key role in mitochondrial function, as well as having antioxidant and anti-inflammatory action. CoQ10 levels are depleted in NAFLD, and studies in animal models and human subjects have indicated that supplementation with CoQ10 can significantly reduce oxidative stress and the inflammation characteristic of NAFLD. In addition, NAFLD patients are at increased risk of developing heart failure, and supplementary CoQ10 may help to reduce this risk. Supplementary CoQ10 is generally well tolerated, with no significant adverse effects reported in long-term use.

Item Type: Article
Additional Information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Gastrointestinal Nursing, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.12968/gasn.2020.18.2.22
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Mark Allen Healthcare
Date Deposited: 29 Apr 2020 08:31
Last Modified: 29 Apr 2020 08:45
DOI or Identification number: 10.12968/gasn.2020.18.2.22
URI: http://researchonline.ljmu.ac.uk/id/eprint/12194

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