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Scutellaria barbata: A Review of Chemical Constituents, Pharmacological Activities and Clinical Application.

Chen, Q, Rahman, K, Wang, S-J, Zhou, S and Zhang, H (2019) Scutellaria barbata: A Review of Chemical Constituents, Pharmacological Activities and Clinical Application. Current Pharmaceutical Design. ISSN 1381-6128

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Abstract

Scutellaria barbata has a long history of medical use in Traditional Chinese Medicine for clearing away heat and toxic material, promoting blood circulation and removing blood stasis, and inducing diuresis to reduce edema. Recent pharmacology investigations have provided evidence for its anti-cancer, bacteriostasis, anti-virus, anti-inflammation, anti-oxidation and immunity enhancement properties. The efficacy of activating blood circulation and removing blood stasis has unique advantages in the treatment of cardiovascular and cerebrovascular diseases. A total of 84 compounds have been isolated from S. barbata and characterized mainly as flavonoids, diterpenoids, followed by polysaccharide, volatile oil and steroids. Peer-reviewed articles published over the last few years were gathered by consulting the databases PubMed, Elsevier, Springer and Chinese Herbal Classics. This review mainly focuses on the pharmacologically active constituents isolated from S. barbata,which have been subjected to in vitro and/or in vivo studies. Although the chemical components, pharmacological activities, toxicology, clinical applications and mechanisms of action of S. barbata have been investigated, many constituents remain unknown. Further investigations are required to investigate the medicinal properties of S. barbata.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology and Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Bentham Science Publishers
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Date Deposited: 14 Feb 2020 10:16
Last Modified: 14 Feb 2020 10:30
DOI or Identification number: 10.2174/1381612825666191216124310
URI: http://researchonline.ljmu.ac.uk/id/eprint/12254

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