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Active behaviour during early development shapes glucocorticoid reactivity

Castillo-Ramírez, LA, Ryu, S and De Marco, RJ (2019) Active behaviour during early development shapes glucocorticoid reactivity. Scientific Reports, 9. ISSN 2045-2322

s41598-019-49388-3 De Marco2019.pdf - Published Version
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Open Access URL: https://www.nature.com/articles/s41598-019-49388-3 (Published version)


TGlucocorticoids are the final effectors of the stress axis, with numerous targets in the central nervous system and the periphery. They are essential for adaptation, yet currently it is unclear how early life events program the glucocorticoid response to stress. Here we provide evidence that involuntary swimming at early developmental stages can reconfigure the cortisol response to homotypic and heterotypic stress in larval zebrafish (Danio rerio), also reducing startle reactivity and increasing spontaneous activity as well as energy efficiency during active behaviour. Collectively, these data identify a role of the genetically malleable zebrafish for linking early life stress with glucocorticoid function in later life.

Item Type: Article
Uncontrolled Keywords: 0601 Biochemistry and Cell Biology, 0299 Other Physical Sciences
Subjects: Q Science > QL Zoology
Divisions: Biological & Environmental Sciences (from Sep 19)
Publisher: Nature Publishing Group
Date Deposited: 25 Feb 2020 12:25
Last Modified: 04 Sep 2021 07:51
DOI or ID number: 10.1038/s41598-019-49388-3
URI: https://researchonline.ljmu.ac.uk/id/eprint/12312
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