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CSF α-synuclein correlates with CSF neurogranin in late-life depression

Bruno, D, Reichert Plaska, C, Clark, D, Zetterberg, H, Blennow, K, Verbeek, M and Pomara, N (2020) CSF α-synuclein correlates with CSF neurogranin in late-life depression. The International Journal of Neuroscience, 131 (4). pp. 357-361. ISSN 0020-7454

CSF α-synuclein correlates with CSF neurogranin in late-life depression.pdf - Accepted Version

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Major depressive disorder (MDD) in late life is linked to increased risk of subsequent dementia, but it is still unclear exactly what pathophysiological mechanisms underpin this link. A potential mechanism related to elevated risk of dementia in MDD is increased levels of α-synuclein (α-Syn), a protein found in presynaptic neuronal terminals. In this study, we examined cerebrospinal fluid (CSF) levels of α-Syn in conjunction with biomarkers of neurodegeneration (amyloid-β 42, total and phospho tau) and synaptic dysfunction (neurogranin), and measures of memory ability, in 27 cognitively intact older individuals with MDD and 19 controls. Our results show that CSF α-Syn levels did not significantly differ across depressed and control participants, but α-Syn was directly associated with neurogranin levels, and indirectly linked to poorer memory ability. All in all, we found that α-Syn may be implicated in the association between late life MDD and synaptic dysfunction, although further research is needed to confirm these results.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in The International Journal of Neuroscience on 31 Mar 2020, available online: http://www.tandfonline.com/10.1080/00207454.2020.1744596
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Psychology (from Sep 2019)
Publisher: Taylor & Francis
Date Deposited: 10 Mar 2020 10:55
Last Modified: 13 Jan 2022 09:45
DOI or ID number: 10.1080/00207454.2020.1744596
URI: https://researchonline.ljmu.ac.uk/id/eprint/12444
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