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CSF α-synuclein correlates with CSF neurogranin in late-life depression

Bruno, D, Reichert Plaska, C, Clark, D, Zetterberg, H, Blennow, K, Verbeek, M and Pomara, N CSF α-synuclein correlates with CSF neurogranin in late-life depression. The International Journal of Neuroscience. ISSN 0020-7454 (Accepted)

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Major depressive disorder (MDD) in late life is linked to increased risk of subsequent dementia, but it is still unclear exactly what pathophysiological mechanisms underpin this link. A potential mechanism related to elevated risk of dementia in MDD is increased levels of α-synuclein (α-Syn), a protein found in presynaptic neuronal terminals. In this study, we examined cerebrospinal fluid (CSF) levels of α-Syn in conjunction with biomarkers of neurodegeneration (amyloid-β 42, total and phospho tau) and synaptic dysfunction (neurogranin), and measures of memory ability, in 27 cognitively intact older individuals with MDD and 19 controls. Our results show that CSF α-Syn levels did not significantly differ across depressed and control participants, but α-Syn was directly associated with neurogranin levels, and indirectly linked to poorer memory ability. All in all, we found that α-Syn may be implicated in the association between late life MDD and synaptic dysfunction, although further research is needed to confirm these results.

Item Type: Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Psychology (new Sep 2019)
Publisher: Taylor & Francis
Date Deposited: 10 Mar 2020 10:55
Last Modified: 10 Mar 2020 11:00
URI: http://researchonline.ljmu.ac.uk/id/eprint/12444

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