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Prospective, single UK centre, comparative study of the predictive values of contrast-enhanced ultrasound compared to time-resolved CT angiography in the detection and characterisation of endoleaks in high risk patients undergoing endovascular aneurysm repair surveillance: a protocol

Roy, IN, Chan, TY, Czanner, G, Wallace, S and Vallabhaneni, SR (2018) Prospective, single UK centre, comparative study of the predictive values of contrast-enhanced ultrasound compared to time-resolved CT angiography in the detection and characterisation of endoleaks in high risk patients undergoing endovascular aneurysm repair surveillance: a protocol. BMJ Open, 8 (4). ISSN 2044-6055

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Abstract

Introduction Diagnosis of endoleaks is imperative to prevent failure of endovascular aneurysm repairs (EVARs). The gold standard for diagnosis of endoleaks is catheter-directed subtraction angiography, which is not a practicable choice for surveillance. CT angiography (CTA) is the historical surveillance modality of choice. Concerns over cost, potential nephrotoxicity of contrast agents and repeated radiation exposure led to colour duplex ultrasound scan (CDUS) becoming an established alternative. CDUS has a lower sensitivity and specificity for endoleaks detection compared to CTA. Contrast-enhanced ultrasound scan (CEUS) represents an improvement of ultrasound imaging but comparisons against CTA report widely varying results, likely due to technical factors of CEUS and limitations of single-phase CTA.
The development of time-resolved CTA (tCTA) offers timing information that much more closely mirrors the dynamic information available from CEUS. Theoretically, these two imaging modalities have the best potential for diagnostic accuracy. The aim of this study will be to compare CEUS to tCTA and investigate the utility of other measurements available from tCTA.
Methods and analysis This is a prospective, single UK centre, comparative study of paired binary diagnostic imaging modalities. Patients identified in routine post-EVAR surveillance as at risk of having a graft-related endoleak will undergo a CEUS and tCTA on the same day. This will allow the first comparison of CEUS to a semidynamic form of CTA. CEUS sensitivity and specificity to endoleak detection will be calculated.
Ethics and dissemination The study has achieved ethical approval. We hope the results will define the diagnostic accuracy of CEUS in comparison to a semidynamic form of CTA, representing a methodological improvement from previous studies. Results will be submitted for presentation at national and international vascular surgeryandradiology meetings. The full results are planned to be published in a medical journal.

Item Type: Article
Uncontrolled Keywords: 1103 Clinical Sciences, 1117 Public Health and Health Services, 1199 Other Medical and Health Sciences
Subjects: R Medicine > R Medicine (General)
Divisions: Applied Mathematics
Publisher: BMJ Publishing
Related URLs:
Date Deposited: 23 Mar 2020 09:10
Last Modified: 23 Mar 2020 09:15
DOI or Identification number: 10.1136/bmjopen-2017-020835
URI: http://researchonline.ljmu.ac.uk/id/eprint/12569

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