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Association of Types of Dietary Fats and All-Cause and Cause-Specific Mortality: A Prospective Cohort Study and Meta-Analysis of Prospective Studies with 1,148,117 Participants

Mazidi, M, Mikhailidis, DP, Sattar, N, Toth, PP, Judd, S, Blaha, MJ, Hernandez, AV, Penson, P and Banach, M Association of Types of Dietary Fats and All-Cause and Cause-Specific Mortality: A Prospective Cohort Study and Meta-Analysis of Prospective Studies with 1,148,117 Participants. Clinical Nutrition. ISSN 0261-5614 (Accepted)

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Abstract

Background: Associations between dietary fats and mortality are unclear.
Methods: We evaluated the relationship between quartiles of total fat, mono-unsaturated (MUFA), polyunsaturated (PUFA) and saturated fatty acid (SFA) consumption, and all-cause, coronary heart disease (CHD), stroke, and type 2 diabetes (T2D)-associated mortality in 24,144 participants from the National Health and Nutrition Examination Surveys (NHANES) 1999-2010. We added our results to a meta-analysis based on searches until November 2018.
Results: In fully adjusted Cox-proportional hazard models in our prospective study, there was an inverse association between total fat (HR: 0.90, 95% confidence interval 0.82, 0.99, Q4 vs Q1) and PUFA (0.81, 0.78-0.84) consumption and all-cause mortality, whereas SFA were associated with the increased mortality (1.08, 1.04-1.11). In the meta-analysis of 29 prospective cohorts (n=1,148,117) we found a significant inverse association between total fat (0.89, 0.82-0.97), MUFA (0.93, 0.87-0.99) and PUFA (0.86, 0.80-0.93) consumption and all-cause mortality. No association was observed between total fat and CVD (0.92, 0.79-1.08) or CHD mortality (1.03 0.99-1.09). A significant association between SFA intake and CHD mortality (1.10, 1.01-1.20) was observed. Neither MUFA nor PUFA were associated with CVD or CHD mortality. Inverse associations were observed between MUFA (0.80, 0.67-0.96) and PUFA (0.84, 0.80-0.90) intakes and stroke mortality.
Conclusions: We showed differential associations of total fat, MUFA and PUFA with all-cause mortality, but not CVD or CHD mortalities. SFA was associated with higher all-cause mortality in NHANES and with CHD mortality in our meta-analysis. The type of fat intake appears to be associated with important health outcomes.

Item Type: Article
Uncontrolled Keywords: 1111 Nutrition and Dietetics
Subjects: T Technology > TX Home economics > TX341 Nutrition. Foods and food supply
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 30 Mar 2020 10:06
Last Modified: 30 Mar 2020 10:06
URI: http://researchonline.ljmu.ac.uk/id/eprint/12608

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