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Application of PLGA nano/microparticle delivery systems for immunomodulation and prevention of allotransplant rejection

Shahbaz, SK, Foroughi, F, Soltaninezhad, E, Jamialahmadi, T, Penson, P and Sahebkar, A (2020) Application of PLGA nano/microparticle delivery systems for immunomodulation and prevention of allotransplant rejection. Expert Opinion on Drug Delivery. ISSN 1742-5247

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Application of PLGA nano microparticle delivery systems for immunomodulation and prevention of allotransplant rejection.pdf - Accepted Version
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Abstract

Introduction: Allograft transplantation is an effective end-point therapy to replace the function of an impaired organ. The main problem associated with allotransplantation is the induction of immune responses that results in acute and chronic graft rejection. To modulate the response of the immune system, transplant recipients generally take high dose immunosuppressant drugs for life. These drugs are associated with serious side effects such as infection with opportunistic pathogens and the development of neoplasia.
Areas covered: We reviewed the obstacles to successful transplantation and PLGA-based strategies to reduce immune-mediated allograft rejection.
Expert opinion: Biomaterial-based approaches using micro- and nanoparticles such as poly (lactic-co-glycolic acid) (PLGA) can be used to achieve controlled release of drugs. This approach decreases the required effective dose of drugs and enables local delivery of these agents to specific tissues and cells, whilst decreasing systemic effects.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Drug Delivery on 28/03/20, available online: http://www.tandfonline.com/10.1080/17425247.2020.1748006
Uncontrolled Keywords: 1115 Pharmacology and Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Taylor & Francis
Date Deposited: 30 Mar 2020 10:17
Last Modified: 30 Mar 2020 10:30
DOI or Identification number: 10.1080/17425247.2020.1748006
URI: http://researchonline.ljmu.ac.uk/id/eprint/12609

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