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Overview of the Advantages and Disadvantages of Different Mucosal Sites for the Delivery of Nanoparticles

Kaneko, K, Osman, NM, Carini, V, Scagnetti, G and Saleem, IY (2020) Overview of the Advantages and Disadvantages of Different Mucosal Sites for the Delivery of Nanoparticles. In: Muttil, P and kunda, N, (eds.) Mucosal Delivery of Drugs and Biologics in Nanoparticles. AAPS Advances in the Pharmaceutical Sciences Series, 41 . Springer Nature. ISBN 3030359107

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Abstract

Nanoparticles (NPs) often improve the efficacy of therapeutic actives, and their delivery to mucosal sites allows for unique and localized effects compared to parenteral delivery. Sites of mucosal surfaces includes the eyes, nasal cavity, lungs, and the entire gastrointestinal tract from mouth to anus, and offers extensive areas for the delivery of therapeutics. However, each mucosal site has unique physiological properties that affect aspects such as stability during the transit to the mucosal surface, release of the active molecules, and absorption of NPs into the body. The required NPs properties also differ based on if the goal is for absorption of intact NPs or release of the active molecules at the mucosal site. Therefore, the interaction of the NPs, with the medium that is in contact with the mucosal surface, the mucus layer, and the epithelial cells, must be considered during the formulation process. This chapter focusses on the advantages and disadvantages of delivering NPs through each major mucosal site and offers indications on NPs properties that may be ideal for each site.

Item Type: Book Section
Uncontrolled Keywords: Mucosal delivery; Nanoparticles; Ocular; Nasal; Lung; Oral; Vaginal
Subjects: Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Springer Nature
Date Deposited: 03 Apr 2020 10:25
Last Modified: 03 Apr 2020 10:25
DOI or Identification number: 10.1007/978-3-030-35910-2_3
Editors: Muttil, P and kunda, N
URI: http://researchonline.ljmu.ac.uk/id/eprint/12638

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