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Barrie, A, Homburg, R, McDowell, G, Brown, J, Kingsland, C and Troup, S (2016) Embryos cultured in a time-lapse system result in superior treatment outcomes: a strict matched pair analysis. Human Fertility, 20 (3). pp. 179-185. ISSN 1464-7273
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Embryos cultured in a time-lapse system result in superior treatment outcomes a strict matched pair analysis..pdf - Accepted Version Download (757kB) | Preview |
Abstract
A retrospective strict matched-pair analysis of 728 treatment cycles between January 2011 and September 2014 was performed. A total of 364 treatment cycles, where all embryos were cultured and examined in EmbryoScope®, were matched to treatment cycles where all the embryos were cultured in a standard incubator with conventional morphological examination. Matching was performed for patient age, number of oocytes collected, treatment type and date of oocyte collection (± six months). The clinical (CPR), implantation (IR), live birth (LBR) and miscarriage rates (MR) were calculated and considered significant when p < 0.05 (Chi-square test). CPR, IR and LBR were found to be significantly higher in the time-lapse system (TLS) group compared to the standard incubation group (CPR = 44.8% versus 36.5%, p = 0.02; IR = 39.3% versus 32.2%, p = 0.03; and LBR = 43.1% versus 33.8%, p = 0.01). Although there was a 5.5% decrease in the MR for the TLS group when compared to the standard incubation group, this result was not statistically significant (18.9% versus 24.4%, p = 0.19). There is a paucity of well-designed studies to confirm that embryos cultured and examined in TLS can result in superior treatment outcomes, and this strict-matched pair analysis with a large cohort of treatment cycles indicates the advantage of using TLS.
| Item Type: | Article |
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| Additional Information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Human Fertility on 24/11/2016, available online: http://www.tandfonline.com/10.1080/14647273.2016.1258735 |
| Uncontrolled Keywords: | 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Taylor & Francis |
| Related URLs: | |
| Date Deposited: | 06 Apr 2020 09:15 |
| Last Modified: | 04 Sep 2021 07:31 |
| DOI or ID number: | 10.1080/14647273.2016.1258735 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/12654 |
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