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High prevalence of albuminuria amongst people who inject drugs: A cross-sectional study.

McGowan, CR, Wright, T, Nitsch, D, Lewer, D, Brathwaite, R, Scott, J, Hope, V, Ciccarone, D, Dunn, J, Gillmore, J, Story, A and Harris, M (2020) High prevalence of albuminuria amongst people who inject drugs: A cross-sectional study. Scientific Reports, 10 (1). ISSN 2045-2322

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Open Access URL: https://www.nature.com/articles/s41598-020-63748-4 (Published version)

Abstract

Albuminuria is a key biomarker for cardiovascular disease and chronic kidney disease. Our study aimed to describe the prevalence of albuminuria amongst people who inject drugs in London and to test any potential associations with demographic characteristics, past diagnoses, and drug preparation and administration practices. We carried out a cross-sectional survey amongst people who use drugs in London. The main outcome measure was any albuminuria including both microalbuminuria and macroalbuminuria. Three-hundred and sixteen samples were tested by local laboratory services. Our study initially employed point-of-care testing methods but this resulted in a high number of false positives. Our findings suggest the prevalence of albuminuria amongst PWID is twice that of the general population at 19% (95%CI 15.3-24.0%). Risk factors associated with albuminuria were HIV (aOR 4.11 [95% CI 1.37-12.38]); followed by overuse of acidifier for dissolving brown heroin prior to injection (aOR 2.10 [95% CI 1.04-4.22]). Albuminuria is high amongst people who inject drugs compared to the general population suggesting the presence of increased cardiovascular and renal pathologies. This is the first study to demonstrate an association with acidifier overuse. Dehydration may be common amongst this population and may affect the diagnostic accuracy of point-of-care testing for albuminuria.

Item Type: Article
Uncontrolled Keywords: 0601 Biochemistry and Cell Biology, 0299 Other Physical Sciences
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine > RA0440 Study and Teaching. Research
Divisions: Public Health Institute
Publisher: Nature Publishing Group
Related URLs:
Date Deposited: 30 Apr 2020 10:25
Last Modified: 30 Apr 2020 10:30
DOI or Identification number: 10.1038/s41598-020-63748-4
URI: http://researchonline.ljmu.ac.uk/id/eprint/12857

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