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Epigenetic control of atherosclerosis via DNA methylation: a new therapeutic target?

Gorabi, AM, Penson, P, Banach, M, Motallebnezhad, M, Jamialahmadi, T and Sahebkar, A Epigenetic control of atherosclerosis via DNA methylation: a new therapeutic target? Life Sciences. ISSN 0024-3205 (Accepted)

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Abstract

Atherosclerosis is a disease in which lipid-laden plaques are developed inside the vessel walls of arteries. The immune system is activated, resulting in inflammation and oxidative stress. Endothelial cells (ECs) are activated, arterial smooth muscle cells (SMCs) proliferate, macrophages are activated, and foam cells are developed, leading to dysfunctional ECs. Epigenetic regulatory mechanisms, including DNA methylation, histone modifications, and microRNAs are involved in the modulation of genes that play distinct roles in several aspects of cell biology and physiology, hence linking environmental stimuli to gene regulation. Recent research has investigated the involvement of DNA methylation in the etiopathogenesis of atherosclerosis, and several studies have documented the role of this mechanism in various aspects of the disease. Regulation of DNA methylation plays a critical role in the integrity of ECs, SMC proliferation and formation of atherosclerotic lesions. In this review, we seek to clarify the role of DNA methylation in the development of atherosclerosis through different mechanisms.

Item Type: Article
Uncontrolled Keywords: 0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 05 May 2020 12:05
Last Modified: 05 May 2020 12:15
Editors: Penson, P
URI: http://researchonline.ljmu.ac.uk/id/eprint/12881

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