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Evolution of the insecticide target Rdl in African Anopheles is driven by interspecific and interkaryotypic introgression.

Grau-Bové, X, Tomlinson, S, O'Reilly, AO, Harding, NJ, Miles, A, Kwiatkowski, D, Donnelly, MJ, Weetman, D and Anopheles gambiae 1000 Genomes Consortium, (2020) Evolution of the insecticide target Rdl in African Anopheles is driven by interspecific and interkaryotypic introgression. Molecular Biology & Evolution. ISSN 0737-4038

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Abstract

The evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin locus (Rdl), a GABA receptor targeted by several insecticides, but most notably by the long-discontinued cyclodiene, dieldrin. The two Rdl resistance mutations (296G and 296S) spread across West and Central African Anopheles via two independent hard selective sweeps that included likely compensatory nearby mutations, and were followed by a rare combination of introgression across species (from A. gambiae and A. arabiensis to A. coluzzii) and across non-concordant karyotypes of the 2La chromosomal inversion. Rdl resistance evolved in the 1950s as the first known adaptation to a large-scale insecticide-based intervention, but the evolutionary lessons from this system highlight contemporary and future dangers for management strategies designed to combat development of resistance in malaria vectors.

Item Type: Article
Uncontrolled Keywords: 0601 Biochemistry and Cell Biology, 0603 Evolutionary Biology, 0604 Genetics
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Q Science > QL Zoology
Divisions: Biological & Environmental Sciences (new Sep 19)
Publisher: Oxford University Press
Related URLs:
Date Deposited: 01 Jun 2020 10:01
Last Modified: 01 Jun 2020 10:01
DOI or Identification number: 10.1093/molbev/msaa128
URI: http://researchonline.ljmu.ac.uk/id/eprint/13026

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