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Phytochemical analysis and biological evaluation of Lagochilus species from Uzbekistan

Akramov, DK, Bachel, M, Bohmdorfer, S, Rosenau, T, Zengin, G, Potthast, A, Nahar, L, Sarker, SD and Mamadalieva, NZ Phytochemical analysis and biological evaluation of Lagochilus species from Uzbekistan. Industrial Crops and Products. ISSN 0926-6690 (Accepted)

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Abstract

The species of the genus Lagochilus (Lamiaceae) are widespread in Central, South-Central, and Eastern Asia. Some of these species are used for their medicinal and therapeutic effects, in particular as hemostatic, anti-inflammatory and anti-epileptic agents. A new iridoid, glucoside 7- cinnamoyllamalbide, along with known compounds lagochilin, 5-hydroxy-7,4'- dimethoxyflavone, daucosterol, β-sitosterol, 8-acetylharpagide were isolated from L. gypsaceus. The high-performance thin-layer chromatography (HPTLC) method was used to determine the chemical fingerprints of 7 different Lagochilus species (L. acutilobus, L. gypsaceus, L. inebrians, L. olgae, L. proskorjakovii, L. setulosus, L. vvedenskyi). Among the tested species, lagochilin content was highest in the endemic species L. inebrians collected from the Djizzakh region of Uzbekistan. In free radical scavenging and reducing power assays, L. inebrans and L. vvedenskyi exhibited the strongest abilities. Regarding cholinesterases, amylase and glucosidase inhibition abilities of the tested samples, 5-hydroxy-7,4'-dimethoxyflavone was the most active compound.

Item Type: Article
Uncontrolled Keywords: 0703 Crop and Pasture Production
Subjects: R Medicine > RM Therapeutics. Pharmacology
S Agriculture > S Agriculture (General)
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 23 Jun 2020 08:56
Last Modified: 23 Jun 2020 09:00
URI: http://researchonline.ljmu.ac.uk/id/eprint/13156

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